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Related Experiment Videos

Metabolic changes during treatment with two different progestogens.

H Refn1, A Kjaer, A M Lebech

  • 1Department of Gynecology and Obstetrics, Frederiksberg Hospital, Copenhagen, Denmark.

American Journal of Obstetrics and Gynecology
|July 1, 1990
PubMed
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This summary is machine-generated.

This study compared two oral contraceptives, finding both effective with few side effects. Gestodene positively influenced lipid metabolism, while levonorgestrel decreased HDL2 cholesterol.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Reproductive Health

Background:

  • Triphasic oral contraceptives are widely used for birth control.
  • Comparing different progestogen components is crucial for understanding their systemic effects.

Purpose of the Study:

  • To compare the contraceptive efficacy, effects on lipid metabolism, and coagulation of two triphasic oral contraceptives containing ethinyl estradiol with either gestodene or levonorgestrel.

Main Methods:

  • A randomized study of 35 women comparing two triphasic oral contraceptives.
  • Serum concentrations of hormones and sex hormone-binding globulin were measured.
  • Lipid profiles and coagulation factors were assessed at baseline and during the third and sixth cycles.

Main Results:

Keywords:
BiologyBlood Coagulation Effects--changesContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--administraction and dosageContraceptive Agents, Progestin--side effectsContraceptive Agents--administraction and dosageContraceptive Agents--side effectsContraceptive Mode Of ActionData CollectionEndocrine SystemEstradiol--analysisEstrogensExaminations And DiagnosesFamily PlanningFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHematological EffectsHemic SystemHormonesLaboratory Examinations And DiagnosesLipid Metabolic Effects--changesLipidsLongitudinal StudiesLuteinizing Hormone--analysisOvulation SuppressionPhysiologyProgestational HormonesProgesterone--analysisResearch MethodologyStudies

Related Experiment Videos

  • Both contraceptives demonstrated good contraceptive effect and cycle control with minor side effects.
  • Gestodene group showed increased apolipoprotein A1 and unchanged HDL2 cholesterol, while levonorgestrel group showed decreased HDL2 cholesterol.
  • Gestodene group experienced a decrease in Antithrombin III and a greater increase in Factor VII compared to the levonorgestrel group.

Conclusions:

  • Gestodene exhibits a favorable impact on lipid metabolism, likely due to lower androgenicity.
  • Gestodene has a minor negative effect on coagulation, deemed clinically insignificant.
  • Both oral contraceptives are effective with comparable safety profiles regarding lipid and coagulation parameters.