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Published on: August 15, 2019
Terminology, concepts, and models in genetic epidemiology
M Dawn Teare1, Mauro F Santibàñez Koref
1Health Services Research, School of Health and Related Research, University of Sheffield, Sheffield, UK.
Abstract:
Genetic epidemiology brings together approaches and techniques developed in mathematical genetics and statistics, medical genetics, quantitative genetics, and epidemiology. In the 1980s, the focus was on the mapping and identification of genes where defects had large effects at the individual level. More recently, statistical and experimental advances have made possible to identify and characterise genes associated with small effects at the individual level. In this chapter, we provide a brief outline of the models, concepts, and terminology used in genetic epidemiology.
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