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Genetic distance and markers used in linkage mapping
Kristina Allen-Brady1, Nicola J Camp
1Genetic Epidemiology Division, Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA.
Methods in Molecular Biology (Clifton, N.J.)
|December 15, 2010
Summary
This chapter details genetic maps and markers essential for linkage analysis. It covers genetic map functions and marker selection, including microsatellite and single nucleotide polymorphism (SNP) markers.
Area of Science:
- Genetics
- Bioinformatics
Background:
- Linkage analysis is crucial for genetic studies.
- Understanding genetic and physical maps is fundamental to this analysis.
Purpose of the Study:
- To explain the role of genetic maps and markers in linkage analysis.
- To differentiate between genetic and physical maps.
- To discuss marker selection strategies.
Main Methods:
- Focus on genetic maps, measured in centiMorgans (cM).
- Contrast with physical maps, measured in base pairs (bp).
- Discusses selection of microsatellite and single nucleotide polymorphism (SNP) markers.
Main Results:
- Genetic maps are the primary type used in linkage analysis.
- Both traditional microsatellite and newer SNP markers are suitable for analysis.
Conclusions:
- Genetic maps and appropriate marker selection are key components of successful linkage analysis.
- The chapter provides foundational knowledge for advanced linkage analysis methodologies.
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