Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A quantitative physicochemical approach to acid-base physiology.

N L Jones1

  • 1Department of Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.

Clinical Biochemistry
|June 1, 1990
PubMed
Summary

This study presents a quantitative approach to acid-base physiology, viewing proton and bicarbonate changes as dependent variables. It simplifies understanding complex physiological interactions and managing acid-base disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of extravascular lung water to diagnose severe reperfusion lung injury following pulmonary endarterectomy: a prospective cohort clinical validation study.

Anaesthesia·2019
Same author

A review of enhanced recovery for thoracic anaesthesia and surgery.

Anaesthesia·2012
Same author

Assessment of patients with chronic airways obstruction.

Canadian family physician Medecin de famille canadien·2010
Same author

Exercise testing in health and disease.

Canadian family physician Medecin de famille canadien·2010
Same author

Pathogenesis of Helicobacter pylori infection.

Current opinion in gastroenterology·2006
Same author

Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells.

Infection and immunity·2006

Area of Science:

  • Physiology
  • Biochemistry
  • Medical Science

Background:

  • Traditional acid-base physiology models have limitations in explaining complex interactions.
  • The Henderson-Hasselbalch equation is often misapplied as a control mechanism.

Purpose of the Study:

  • To present a quantitative, systems-based approach to acid-base physiology.
  • To reframe the understanding of acid-base disturbances by identifying independent variables.

Main Methods:

  • Utilizing quantitative relationships between physiological systems.
  • Employing independent variables such as strong ion difference (SID), weak acids (AtOt), and carbon dioxide (PCO2).
  • Solving a series of equations computationally to describe system interactions.

Related Experiment Videos

Main Results:

  • Proton (H+) and bicarbonate ([HCO3]) changes are identified as dependent, not primary, variables.
  • The approach offers a simplified, quantitative description of acid-base homeostasis.
  • Facilitates understanding of ion shifts, renal control, metabolism, and disorder management.

Conclusions:

  • The proposed quantitative, systems-based approach provides a more accurate and comprehensive understanding of acid-base physiology.
  • This model simplifies the interpretation of complex physiological events and clinical acid-base disorders.