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Related Concept Videos

Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

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Related Experiment Video

Updated: Jun 6, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Small non-coding RNAs in disease development and host-pathogen interactions.

Mathieu Rederstorff1, Alexander Hüttenhofer

  • 1Innsbruck Medical University, Biocenter, Division for Genomics and RNomics, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria.

Current Opinion in Molecular Therapeutics
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are vital in health and disease. This review details ncRNA roles in genetic disorders, CNS diseases, cancers, and infectious diseases, highlighting diagnostic and therapeutic potential.

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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators of physiological processes.
  • Dysregulation of ncRNAs is linked to various pathological conditions, including cancer.

Purpose of the Study:

  • To review the roles of small ncRNAs in infectious and genetic disorders.
  • To focus on microRNA (miRNA) de-regulation and other ncRNAs like small nucleolar RNAs (snoRNAs) in human diseases.
  • To explore ncRNA-based diagnostic strategies and therapeutic approaches.

Main Methods:

  • Literature review and synthesis of existing research on ncRNAs in disease.
  • Analysis of the impact of miRNA and snoRNA de-regulation.
  • Examination of current and emerging diagnostic and therapeutic applications.

Main Results:

  • Small ncRNAs are implicated in a wide range of diseases, including CNS disorders and cancers.
  • MicroRNA de-regulation significantly impacts human diseases.
  • Other ncRNAs, such as snoRNAs, also play roles in disease pathogenesis.

Conclusions:

  • ncRNAs are critical players in human health and disease.
  • ncRNA analysis offers promising diagnostic potential.
  • ncRNAs represent novel targets and tools for disease treatment.