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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

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Published on: August 30, 2014

Sublingual immunotherapy for allergic rhinitis.

Suzana Radulovic¹, Moises A Calderon, Duncan Wilson

¹LEAP Study Team, Paediatric Allergy Research Department, St. Thomas' Hospital, Lambeth Palace Road, London, UK, SE1 7EH.

The Cochrane Database of Systematic Reviews

|December 15, 2010

Summary

This summary is machine-generated.

Sublingual immunotherapy (SLIT) significantly reduces allergic rhinitis symptoms and medication needs in adults and children. This safe treatment option showed no severe systemic reactions in trials.

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Area of Science:

Allergy and Immunology
Pharmacology
Clinical Trials

Background:

Allergic rhinitis significantly impacts quality of life.
Injectable immunotherapy has risks of severe systemic reactions.
Sublingual immunotherapy (SLIT) offers a potentially safer alternative.

Purpose of the Study:

To evaluate the efficacy and safety of sublingual immunotherapy for allergic rhinitis.
Assess SLIT's impact on symptoms and medication use in adults and children.

Main Methods:

Systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials.
Included 60 trials with 2333 participants receiving SLIT and 2256 on placebo.
Analyzed symptom and medication scores, and adverse events.

Main Results:

SLIT significantly reduced allergic rhinitis symptoms (SMD -0.49) and medication requirements (SMD -0.32) compared to placebo.
No severe systemic reactions or anaphylaxis were reported in the included trials.
Reported systemic reactions did not require adrenaline administration.

Conclusions:

Sublingual immunotherapy is an effective treatment for allergic rhinitis.
SLIT has a proven safety profile as a route of administration.
This updated review confirms findings from the original 2003 Cochrane Review.