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Interventions for treating sexual dysfunction in patients with chronic kidney disease
Mariacristina Vecchio1, Sankar D Navaneethan, David W Johnson
1Clinical Pharmacology and Epidemiology, Mario Negri Sud Consortium, Via Nazionale 8/A, Santa Maria Imbaro, Chieti, Italy, 66030.
The Cochrane Database of Systematic Reviews
|December 15, 2010
Summary
Phosphodiesterase-5 inhibitors (PDE5i) and zinc show promise for treating sexual dysfunction in men with chronic kidney disease (CKD). However, limited evidence supports their routine use, highlighting a need for more research in both male and female CKD patients.
Area of Science:
- Nephrology
- Urology
- Pharmacology
Background:
- Sexual dysfunction is prevalent in chronic kidney disease (CKD) patients but remains understudied.
- Existing treatments for sexual dysfunction raise concerns regarding efficacy and safety in CKD populations.
Purpose of the Study:
- To assess the benefits and harms of current interventions for sexual dysfunction in individuals with CKD.
- To evaluate pharmacological and non-pharmacological treatments for sexual dysfunction in male and female CKD patients.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) and quasi-RCTs.
- Searched specialized registers and databases (Cochrane Renal Group, CENTRAL, MEDLINE, EMBASE) up to October 2010.
- Data extraction and quality assessment by two independent reviewers; random-effects model for meta-analysis.
Main Results:
- Fifteen studies (352 patients) were included; only one study involved women.
- Phosphodiesterase-5 inhibitors (PDE5i) significantly improved erectile function scores (IIEF-5).
- Oral zinc supplementation improved testosterone levels, while zinc added to dialysate did not show significant effects.
Conclusions:
- PDE5i and zinc are potential treatments for male sexual dysfunction in CKD, but evidence for routine use is limited.
- Further research is needed to address the significant burden of sexual dysfunction in both male and female CKD patients.
- There is a lack of studies on various non-pharmacological and other pharmacological interventions for sexual dysfunction in CKD.
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