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[Effects of extremely low magnetic field on acute and chronic arthritis of rats]
Xiu-Qi Bao1, Yi-Jun Shi, Yu-Xia Zhang
1Bioelectromagnetics Lab, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100080, China.
Aim:
To investigate the effects of extremely low magnetic field on acute and chronic arthritis of rats.
Methods:
The acute arthritis animal models were built by the right thenar hypodermic injection of carrageenan. Then they were exposed to magnetic field for 6 hours and 8 hours, respectively. The chronic arthritis animal models were built by the right thenar hypodermic injection of complete freund's adjuvant. They were exposed to magnetic field for 7 days and 6 hours each day after the secondary affection appeared 15 days later. The swelling and inflammatory cytokine were observed in both the acute and chronic arthritis models.
Results:
The ankle and thenar swellings decreased in both the acute and chronic arthritis models after different time exposure. The cytokine of serum and articular lixivium did not change in 6 hours exposed groups of acute arthritis models. The serum IL-6 and articular lixivium IL-6, TNF-alpha decreased compared with sham groups. Though the rest indexes were unchanged, they had the tendency of decrease.
Conclusion:
The extremely low magnetic field has the effects of restraining acute and chronic arthritis of rats, and can also partially restrain the cytokines when the rats were exposed for 8 hours. The mechanisms need to be further investigated.