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Published on: January 7, 2019
Oxygen-generating nanofiber cell scaffolds with antimicrobial properties
Junping Wang1, Yizhou Zhu, Harinder K Bawa
1Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States.
ACS Applied Materials & Interfaces
|December 16, 2010
Summary
Antimicrobial polycaprolactone (PCL) nanofibers incorporating calcium peroxide resist bacterial growth. These oxygen-releasing nanofibers promote healthy tissue integration after an initial short-term effect.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Antimicrobial Materials
Background:
- Next-generation biomaterials require both tissue integration and infection resistance.
- Biomaterial-associated infections pose a significant clinical challenge.
- Developing materials with inherent antimicrobial properties is crucial.
Purpose of the Study:
- To fabricate antimicrobial polycaprolactone (PCL) nanofibers.
- To incorporate calcium peroxide into PCL nanofibers for antimicrobial properties.
- To evaluate the antimicrobial efficacy and cytocompatibility of these nanofibers.
Main Methods:
- Fabrication of PCL nanofibers with varying calcium peroxide ratios (1%, 5%, 10%) via electrospinning.
- Incorporation of ascorbic acid as a potential modulator.
- Antimicrobial testing against E. coli and S. epidemidis.
- In vitro assessment of osteoblast viability and morphology.
Main Results:
- Nanofibers exhibited significant burst release of calcium peroxide.
- Effective inhibition of E. coli and S. epidemidis growth was confirmed.
- Initial cytotoxicity to osteoblasts observed within 24 hours.
- Healthy osteoblast viability and morphology after 4 days of culture.
Conclusions:
- Oxygen-generating PCL nanofibers provide a short-term, peroxide-based antimicrobial effect.
- These nanofibers maintain favorable tissue integration properties.
- The developed material holds potential for preventing biomaterial-associated infections.
