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Updated: Jun 6, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
[A study on the relationship between glutathione S-transferases gene polymorphism and susceptibility response to
Hui-qin Yan1, Xue-chuan Sun, Kong-xiang Liu
1Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine of Sichuan University, Chengdu 610041, China.
Aim:
To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia.
Methods:
In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP.
Results:
The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese (P < 0.05), OR = 1.86 (95% CI = 1.01-3.39), and also for GSTP(1-105) mutant genotype in two groups (P < 0.01), OR = 2.19 (95% CI = 1.16-4.13). There was significant difference between A allele and G allele of GSTP(1-105) groups (P < 0.01). There was no difference for GSTM1 null genotype between two groups (P > 0.05), OR = 0.78 (95% CI = 0.43 - 1.42).
Conclusion:
GSTT1 and GSTP(1-105) genotype may be associated with susceptibility response to altitude hypoxia.
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