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Published on: May 5, 2020
[Effect of one month treatment with dutasteride on transurethral resection of the prostate]
J A Arratia-Maqueo1, R Garza-Cortés, L S Gómez-Guerra
1Servicio de Urología, Hospital Universitario «Dr. José E. González» UANL Monterrey, NL México.
Insights
Dutasteride did not significantly reduce perioperative bleeding during Transurethral Resection of Prostate (TURP). Some patients improved symptoms, avoiding surgery, but key surgical outcomes showed no significant difference.
Area of Science:
- Urology
- Pharmacology
Background:
- Transurethral Resection of Prostate (TURP) is a common procedure for benign prostatic hyperplasia.
- Perioperative bleeding is a potential complication of TURP.
Purpose of the Study:
- To evaluate the effect of dutasteride on perioperative bleeding during TURP.
- To assess dutasteride's impact on hemoglobin loss and resected tissue volume.
Main Methods:
- A non-randomized study included 40 patients undergoing TURP.
- Patients were divided into two groups: 24 treated with dutasteride pre-TURP and 16 controls.
- Hemoglobin difference, prostatic volume, and resected tissue were recorded; the surgeon was blinded.
Main Results:
- 33% of patients in the dutasteride group improved symptoms and avoided TURP.
- No statistically significant difference in mean hemoglobin loss between groups (0.11 gr/dl).
- No significant differences observed in prostatic volume or resected tissue amount.
Conclusions:
- Dutasteride did not significantly impact perioperative bleeding or surgical variables in this study.
- Findings are limited by non-randomized design and small sample size.
Objective:
Evaluate the effect of dutasteride in perioperative bleeding during Transurethral Resection of Prostate (TURP).
Materials And Methods:
Forty consecutive patients with criteria for TURP were included. Finasteride/dutasteride use, renal impairment, prostate < 30 cc, age <50 were excluded. Patients were divided in 2 groups. Group 1: 24 consecutive patients treated with dutasteride 0.5 mg/day/30-days prior TURP. Group 2: 16 without treatment. Prostatic volume, difference in hemoglobin pre/post TURP, duration and amount of resected tissue were recorded. Surgeon was blinded.
Statistical Analysis:
Multiple linear regression, Mann-Whitney and student t-tests were used.
Results:
In group 1, 33% (8) improved their lower urinary tract symptoms and skipped TURP. Mean Hemoglobin loss difference between groups was 0.11 gr/dl (CI 95% -0.55; 0.77, p=0.88). There was no statistical difference among variables. No positive or negative predictive values in the linear regression model.
Conclusion:
Dutasteride did not significantly impact the studied variables in these non randomized and small sample size settings.
