[Effect of body mass index on PSA in northeast Mexican patients]
L S Gómez-Guerra1, A U Hernández-Torres, A Blanco-Guzmán
1Servicio de Urología, Hospital Universitario Dr. José E. González, UANL, Monterrey, NL, México.
Objective:
To evaluate the effect of body mass index (BMI) on PSA in northeast Mexican patients included in prostate cancer (Pca) early detection screening campaigns offered by our institution.
Material And Methods:
One hundred and ninety seven patients came voluntarily to our Pca early detection screening campaigns.
Exclusion Criteria:
PSA >10 ng/dl, patients on 5-α Reductase inhibitors or hormonal replacement. Overweight and obesity were considered when BMI was between 25-29.9 and ≥30 kg/m(2) respectively. Simple linear and multiple regression were used in the statistical analysis. Mean and standard deviation were utilized to evaluate spread and normal distribution. P values <0.05 were considered statistically significant.
Results:
One hundred and fifty two patients were included in this study. Forty four percent (83) and 30.3%(46) presented with overweight and obesity, respectively. Mean BMI was 28.16 kg/m(2) (SD 1.77). A statistically significant negative effect of BMI on PSA was observed in the linear regression. This effect persisted when adjusted for age in the multiple regression model. A decrease of 0.085 ng/dl for every unit of BMI (p <0.001) was observed in the simple linear regression. This value was 0.07 in the multiple regression (p=0.006) CONCLUSIONS: A higher negative effect of BMI on PSA was found in comparison to published literature. A higher proportion of patients with BMI >25 kg/m(2) than the national mean was observed. A multicentric national study is needed in order to challenge these results.
