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Alternatives to clopidogrel for acute coronary syndromes: Prasugrel or ticagrelor?

Giuseppe Biondi-Zoccai1, Marzia Lotrionte, Fiorenzo Gaita

  • 1Giuseppe Biondi-Zoccai, Marzia Lotrionte, Fiorenzo Gaita, Division of Cardiology, University of Turin, San Giovanni Battista "Molinette" Hospital, 10126 Turin, Italy; Unit for Heart Failure and Cardiac Rehabilitation, Catholic University, 00136 Rome, Italy.

World Journal of Cardiology
|December 17, 2010
PubMed

Insights

Clopidogrel, prasugrel, and ticagrelor are antiplatelet agents used for acute coronary syndromes. This review evaluates their evidence, efficacy, and side effects to guide clinical choices.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Clopidogrel is a widely used antiplatelet medication for acute coronary syndromes and post-stenting.
  • Its effectiveness is questioned due to variable patient response and newer agents like prasugrel and ticagrelor.

Purpose of the Study:

  • To review the evidence supporting clopidogrel's use.
  • To compare clopidogrel with prasugrel and ticagrelor.
  • To discuss the pros and cons of each antiplatelet agent.

Main Methods:

  • Literature review of clinical studies and trials.
  • Comparative analysis of antiplatelet efficacy and safety data.
  • Synthesis of current evidence on clopidogrel, prasugrel, and ticagrelor.

Main Results:

  • Evidence for clopidogrel's efficacy is presented.
  • Prasugrel's approval and role are discussed.
  • Ticagrelor's future clinical application is considered.

Conclusions:

  • A balanced view of clopidogrel, prasugrel, and ticagrelor is provided.
  • Arguments for and against each agent are outlined.
  • Guidance for selecting appropriate antiplatelet therapy is offered.

Keywords:
Acute coronary syndromeClopidogrelPrasugrelTicagrelor

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