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New approach to peritoneal surface malignancies.

Antonio Macrì¹

¹Antonio Macrì, Department of Human Pathology, General Surgery Unit, University of Messina, 98125 Messina, Italy.

World Journal of Gastrointestinal Oncology

|December 17, 2010

Summary

Peritoneal surface malignancies (PSM) have a poor prognosis. This review highlights innovative treatments like cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis and other PSMs.

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Area of Science:

Oncology
Surgical Oncology
Gastrointestinal Oncology

Background:

Peritoneal surface malignancies (PSM) encompass peritoneal carcinomatosis, pseudomyxoma peritonei, and primary peritoneal tumors.
These conditions present significant challenges in cancer treatment due to their unfavorable prognosis.

Purpose of the Study:

To discuss innovative treatment strategies for PSM.
To highlight the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in managing PSM.

Main Methods:

Review of current international research on PSM treatment.
Focus on surgical and chemotherapeutic approaches.

Main Results:

Cytoreductive surgery combined with HIPEC represents a promising approach for PSM.

Keywords:

Colorectal cancer Cytoreductive surgery Gastric cancer HIPEC Hyperthermic intraperitoneal chemotherapy Ovarian cancer Peritoneal carcinomatosis Peritoneal mesothelioma Peritoneal surface malignancy Pseudomyxoma peritonei

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The treatment paradigm is evolving, moving towards evidence-based practices.

Conclusions:

Innovative treatments, particularly cytoreductive surgery and HIPEC, offer new hope for PSM patients.
Further research and data are needed to solidify the evidence base for these advanced therapies.