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Updated: Jul 24, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
[Gonadotropic function of the hypophysis in girls with delayed puberty]
Abstract:
Radioimmune assay of serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 216 girls aged 13-18 years with pubertal delay (PD) unrelated to gonadal dysgenesis have shown that LH and FSH levels were normal in 48.1%; one or both gonadotropins were decreased in 17.1%, only LH level was increased in 13.9% and only FSH level in 12.6%. Hypergonadotropinemia was seen in 8.3% of the patients. Bioassay of total gonadotropin excretion was performed in 117 patients. Comparison of the radioimmune and biological assays suggested misproduction of the biologically active gonadotropins in a proportion of girls with PD. Hypoestrogenism in normogonadotropic PD appears to be related to regional blood and lymph flow disturbance.
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