[Secondary amenorrhea caused by hypothyroidism]

The status of the reproductive and pituitary-thyroid systems has been elucidated in patients with amenorrhea secondary to hypothyroidism. Hypothyroidism as a major pathogenetic determinant accounted for 4.3% of secondary amenorrhea. Subclinical thyroid dysfunctions which were detectable only with hormonal assays were found to be prevalent. Clinical and hormonal criteria for diagnosis of this pathogenetic type of secondary amenorrhea were obtained, and efficacy of combined therapy for hypothyroidism, menstrual and reproductive dysfunction was evaluated.