Related Experiment Video
Updated: Jun 6, 2026
Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice
Hirayuki Enomoto1, Hideji Nakamura, Naoko Komatsu-Kanatani
1Hirayuki Enomoto, Hideji Nakamura, Teruhisa Yamamoto, Weidong Liu, Shuhei Nishiguchi, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Aim:
To investigate the role of hepatoma-derived growth factor (HDGF) in liver development, especially in the hepatocyte differentiation.
Methods:
We generated transgenic mice which overexpressed HDGF in hepatocytes under the transcriptional control of mouse albumin promoter/enhancer. To examine the effects of HDGF overexpression on hepatocyte differentiation, we investigated the expression patterns of the differentiation marker genes.
Results:
The HDGF transgenic mice developed normally and showed no apparent abnormality in the liver. However, the gene expression patterns of the liver in adult transgenic mice were similar to those of the neonatal liver in control mice.
Conclusion:
These findings suggest that HDGF-overexpression partially suppresses hepatocyte maturation.
More Related Videos
08:50In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
Published on: April 18, 2025
09:29Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016