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Updated: Jun 6, 2026

Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Aqueous synthesis of CdTe/CdSe core/shell quantum dots as pH-sensitive fluorescence probe for the determination of
Shan-Shan Yang1, Cui-Ling Ren, Zhen-Yang Zhang
1National Key Laboratory of Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Abstract:
By controlling the reflux time and the quantity of the shell materials, different sizes of thioglycollic acid (TGA) modified CdTe/CdSe core/shell quantum dots were synthesized in aqueous solution. This type of QDs was used for sensitive and selective determination of ascorbic acid in commercial tablets. Under optimal conditions, a good linearity was observed between the relative fluorescence (FL) intensity and the concentration of ascorbic acid in the range of 4.0 to 64.0 μg/mL with a correlation coefficient of 0.9968. The limit of detection was 2.4 μg/mL. This method was applied to the determination of the ascorbic acid in Vitamin C tablets and Vitamin C Yinqiao pills, and satisfactory results were obtained.

