Related Experiment Video
Updated: Jun 6, 2026
13:42
Gold Nanoparticle Synthesis
Published on: July 10, 2021
Nitric oxide releasing nanoparticle synthesis and characterization
George Han1, Adam J Friedman, Joel M Friedman
1Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA. ghan@aecom.yu.edu
Methods in Molecular Biology (Clifton, N.J.)
|December 17, 2010
Summary
Researchers developed a novel sol-gel/glass hybrid system for sustained nitric oxide (NO) delivery. This stable powder releases therapeutic NO levels over hours to days in aqueous environments, ideal for research and clinical applications.
Area of Science:
- Biomaterials Science
- Medical Chemistry
- Physiology
Background:
- Nitric oxide (NO) has significant therapeutic potential but lacks effective, sustained delivery systems.
- Existing methods for NO delivery are often impractical or not cost-effective for widespread use.
Purpose of the Study:
- To develop a reliable, cost-effective, and practical sustained delivery system for nitric oxide.
- To demonstrate controlled and sustained release of NO from a novel material.
Main Methods:
- Utilized a sol-gel/glass hybrid system to create a stable, dry powder.
- Investigated the release kinetics of NO upon exposure to an aqueous environment.
Main Results:
- Achieved controlled and sustained release of nitric oxide from the sol-gel/glass hybrid material.
- Demonstrated release of therapeutic levels of NO over several hours to days.
Conclusions:
- The developed sol-gel/glass hybrid system offers a promising solution for sustained nitric oxide delivery.
- This material is suitable for evaluating NO efficacy in both clinical and research settings.
