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Water-based DNF@PLA microcapsules with excellent interface properties enhancing insecticidal activity against
Chen Qin1, Yue Gao1, Bo Zhang2
1State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Background:
Dinotefuran (DNF) is a third-generation neonicotinoid and renders broad-spectrum efficacy against piercing-sucking pests. Among these, Nilaparvata lugens, one of the most destructive piercing-sucking pests, is highly susceptible to DNF. However, traditional DNF formulations tend to leach out and exhibit a low utilization rate. This work developed microcapsules using water-in-oil (W/O) emulsions as templates in combination with the eco-friendly material polylactide (DNF@PLA).
Results:
This study employed a variable-controlled method to prepare DNF@PLA. The drug loading and encapsulation efficiency of DNF@PLA were 11.13% and 77.52%, respectively. Compared to commercial suspension agent (SC), DNF@PLA exhibited excellent temperature responsiveness and a 30% improvement in photodegradation resistance. The DNF@PLA exhibited superior control efficacy against Nilaparvata lugens (LC50 = 0.397 mg L-1) than the commercial SC (LC50 = 0.646 mg L-1).
Conclusion:
This study demonstrated that DNF@PLA exhibited superior interfacial properties and insecticidal efficacy, enabling reduced surfactant requirements and promising practical applications. © 2026 Society of Chemical Industry.
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