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Water-based DNF@PLA microcapsules with excellent interface properties enhancing insecticidal activity against
Chen Qin1, Yue Gao1, Bo Zhang2
1State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Pest Management Science
|July 15, 2026
Summary
This study developed polylactide microcapsules (DNF@PLA) for dinotefuran (DNF), improving pest control and environmental resistance. The new formulation shows enhanced efficacy against Nilaparvata lugens compared to commercial products.
Area of Science:
- Agricultural Science
- Materials Science
- Environmental Science
Background:
- Dinotefuran (DNF) is a third-generation neonicotinoid insecticide effective against piercing-sucking pests.
- Nilaparvata lugens is a highly destructive pest susceptible to DNF.
- Traditional DNF formulations suffer from leaching and low utilization rates.
Purpose of the Study:
- To develop an improved DNF formulation using polylactide microcapsules (DNF@PLA).
- To enhance the stability and efficacy of DNF against Nilaparvata lugens.
- To reduce environmental impact associated with traditional insecticide formulations.
Main Methods:
- Preparation of DNF@PLA microcapsules using water-in-oil (W/O) emulsions as templates.
- Characterization of DNF@PLA, including drug loading and encapsulation efficiency.
- Comparative efficacy testing against Nilaparvata lugens against commercial suspension agents (SC).
Main Results:
- DNF@PLA achieved a drug loading of 11.13% and an encapsulation efficiency of 77.52%.
- DNF@PLA demonstrated superior temperature responsiveness and 30% increased photodegradation resistance compared to SC.
- DNF@PLA showed significantly higher control efficacy against Nilaparvata lugens (LC50 = 0.397 mg L-1) than commercial SC (LC50 = 0.646 mg L-1).
Conclusions:
- DNF@PLA microcapsules offer improved interfacial properties and insecticidal efficacy.
- The DNF@PLA formulation requires reduced surfactant usage.
- DNF@PLA presents promising potential for practical applications in pest management.
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