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Updated: Jun 5, 2026
06:06
Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
Global prevailing and emerging pediatric pneumococcal serotypes
E David G McIntosh1, Ralf R Reinert
1Novartis Vaccines, Hullenbergweg 83-85, Amsterdam 1101CL, The Netherlands. david.mcintosh@novartis.com
Expert Review of Vaccines
|December 18, 2010
Summary
Pneumococcal conjugate vaccines (PCV7) reduced invasive pneumococcal disease (IPD). However, non-PCV7 serotypes (NVTs) are increasing, necessitating ongoing monitoring of emerging strains like 1, 3, 5, 6A, 7F, and 19A.
Area of Science:
- Pediatric infectious diseases
- Vaccinology
- Microbial epidemiology
Background:
- Streptococcus pneumoniae causes significant global child mortality.
- The 7-valent pneumococcal conjugate vaccine (PCV7) reduced invasive pneumococcal disease (IPD) incidence.
- Emerging non-PCV7 vaccine serotypes (NVTs) are increasingly causing IPD.
Purpose of the Study:
- To provide a global summary of prevailing and emerging NVT serotypes causing IPD in children.
- To assess the impact of PCV7, PCV10, and PCV13 on IPD serotypes.
- To highlight the need for ongoing surveillance of NVT seroprevalence.
Main Methods:
- Comprehensive global literature review.
- Analysis of seroepidemiological data on IPD.
- Summary of prevailing and emerging NVT serotypes.
Main Results:
- Globally emerging or persistent NVTs include serotypes 1, 3, 5, 6A, 7F, and 19A.
- PCV10 and PCV13 cover significant proportions of disease burden in developed countries (65-85% and 80-90%, respectively).
- Increased IPD incidence due to NVTs is reported post-PCV7 introduction.
Conclusions:
- NVTs pose a growing challenge to pneumococcal disease control.
- Current vaccines (PCV10, PCV13) cover a substantial disease burden but do not eliminate NVT risk.
- Continuous monitoring of NVT seroprevalence is crucial for public health strategies.
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