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Global prevailing and emerging pediatric pneumococcal serotypes

E David G McIntosh1, Ralf R Reinert

  • 1Novartis Vaccines, Hullenbergweg 83-85, Amsterdam 1101CL, The Netherlands. david.mcintosh@novartis.com

Expert Review of Vaccines
|December 18, 2010
PubMed

Insights

Pneumococcal conjugate vaccines (PCV7) reduced invasive pneumococcal disease (IPD). However, non-PCV7 serotypes (NVTs) are increasing, necessitating ongoing monitoring of emerging strains like 1, 3, 5, 6A, 7F, and 19A.

Area of Science:

  • Pediatric infectious diseases
  • Vaccinology
  • Microbial epidemiology

Background:

  • Streptococcus pneumoniae causes significant global child mortality.
  • The 7-valent pneumococcal conjugate vaccine (PCV7) reduced invasive pneumococcal disease (IPD) incidence.
  • Emerging non-PCV7 vaccine serotypes (NVTs) are increasingly causing IPD.

Purpose of the Study:

  • To provide a global summary of prevailing and emerging NVT serotypes causing IPD in children.
  • To assess the impact of PCV7, PCV10, and PCV13 on IPD serotypes.
  • To highlight the need for ongoing surveillance of NVT seroprevalence.

Main Methods:

  • Comprehensive global literature review.
  • Analysis of seroepidemiological data on IPD.
  • Summary of prevailing and emerging NVT serotypes.

Main Results:

  • Globally emerging or persistent NVTs include serotypes 1, 3, 5, 6A, 7F, and 19A.
  • PCV10 and PCV13 cover significant proportions of disease burden in developed countries (65-85% and 80-90%, respectively).
  • Increased IPD incidence due to NVTs is reported post-PCV7 introduction.

Conclusions:

  • NVTs pose a growing challenge to pneumococcal disease control.
  • Current vaccines (PCV10, PCV13) cover a substantial disease burden but do not eliminate NVT risk.
  • Continuous monitoring of NVT seroprevalence is crucial for public health strategies.

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