[Action of Tiapride on wakefulness]

A "blind" study of the action of tiapride on vigilance was carried out in 3 healthy volunteers using polygraph recordings and psychometric tests. A total of 48 recordings were made in order to study the effects during initial treatment, long-term administration of a dose of 299 mg/day, and the rebound period, we also studied the effect of a single dose of 400 mg of tiapride. No quanlitative or quantitative changes in the polygraph recordings were noted. The psychological tests showed reduction of highest scroes and lowering of the overal efficiency level, but diminished attention during treatment was not observed.