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Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
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[Neurological dysfunction induced by bilirrubin].

J Campistol1, H Galvez, A García Cazorla

  • 1Servicio de Neurología, Hospital Universitario Sant Joan de Dèu, Barcelona, España. campistol@hsjdbcn.org

Neurologia (Barcelona, Spain)
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Bilirubin encephalopathy, a brain injury from high bilirubin levels, is increasingly seen in newborns. This study reviews cases, highlighting neuroimaging findings and the need for prevention strategies.

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Area of Science:

  • Neurology
  • Neonatology
  • Neuroscience

Context:

  • Kernicterus is an outdated term for bilirubin-induced brain injury.
  • Bilirubin encephalopathy or dysfunction is the preferred terminology.
  • Prevalence is decreasing in developed nations.

Purpose:

  • To review a series of 7 patients with bilirubin encephalopathy.
  • To analyze clinical signs, neuroimaging, and outcomes.
  • To identify factors contributing to increased incidence.

Summary:

  • Diverse etiological factors contribute to hyperbilirubinemia.
  • Consistent neuroimaging finding: T1 hyperintensity in the nucleus pallidus.
  • Survivors developed neurological signs correlated with clinical and imaging data.

Impact:

  • An increase in bilirubin encephalopathy cases is observed.
  • Contributing factors include increased survival of low birth weight infants, immigration, and advanced neuroimaging.
  • Prevention and management are critical challenges for neonatologists and neuropaediatricians.