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Updated: Jun 5, 2026

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines
Published on: June 17, 2017
Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development
Michael J Shapiro1, Virginia Smith Shapiro
1Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.
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