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Updated: Jun 5, 2026

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis
09:04

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

Published on: July 26, 2018

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer

Lars Petter Jordheim1, Pascal Sève, Olivier Trédan

  • 1INSERM U590, Laboratoire de Cytologie Analytique, Faculte de Medecine Rockefeller, Universite Claude Bernard Lyon I, 69008 Lyon, France. lars-petter.jordheim@univ-lyon1.fr

The Lancet. Oncology
|December 18, 2010
PubMed

Insights

The human ribonucleotide reductase large subunit (RRM1) is crucial for DNA synthesis and cancer progression. Assessing RRM1 may predict patient response to gemcitabine chemotherapy.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The large subunit of human ribonucleotide reductase (RRM1) plays a key role in DNA synthesis and is implicated in cell proliferation, migration, tumor development, and metastasis.
  • RRM1 is a cellular target for the chemotherapy drug gemcitabine, making it relevant for cancer treatment strategies.

Purpose of the Study:

  • To review preclinical and clinical studies evaluating RRM1 as a biomarker in various cancers.
  • To discuss the potential of RRM1 assessment in predicting patient outcomes, particularly with gemcitabine treatment.

Main Methods:

  • Review of existing preclinical and clinical research on RRM1 assessment.
  • Analysis of studies investigating RRM1 mRNA expression and genetic variants in cancer patients.
  • Examination of RRM1's association with clinical outcomes in patients treated with gemcitabine.

Main Results:

  • RRM1's involvement in critical cellular processes and its role as a gemcitabine target have been established.
  • Studies in non-small-cell lung cancer, pancreatic cancer, breast cancer, and biliary tract cancer have explored RRM1's prognostic and predictive value.
  • RRM1 mRNA expression and genetic variants have shown associations with clinical outcomes in some cancer patient cohorts.

Conclusions:

  • RRM1 is a clinically pertinent biomarker with potential in cancer patient management.
  • Further development and validation of RRM1 assessment methods are warranted.
  • RRM1 evaluation could aid in personalizing gemcitabine-based cancer therapies.

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