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Updated: May 31, 2026

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
Published on: August 11, 2014
When more target antigen expression is less
1Université Claude Bernard Lyon 1, INSERM U-1052, CNRS 5286, Centre Léon Bérard, Hospices Civils de Lyon, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France.
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Resistance to antibody drug conjugates (ADCs) may be due to low target antigen expression resulting in reduced intracellular payload concentration. In this issue of Cancer Cell, Wang et al. show that increased target antigen NECTIN4 expression is associated with reduced NECTIN4-ADC internalization and enhanced extracellular ADC release in a resistant tumor cell subpopulation.
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