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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Related Experiment Video

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Orthotopic Mouse Model of Colorectal Cancer
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Beyond Rodents: Alternative Animal Models in Colorectal Cancer Research.

Wei Xiong1,2, Solène Favier1, Ting Wu1

  • 1LabEx Dev2CAN, Institut Convergence Plascan, Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Université de Lyon, CEDEX 08, 69008 Lyon, France.

International Journal of Molecular Sciences
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Exploring non-rodent models for colorectal cancer (CRC) research is crucial for advancing treatment. Alternative models like zebrafish and fruit flies offer unique insights into CRC mechanisms and drug resistance.

Keywords:
chorioallantoic membrane modelcolorectal cancerdrug resistancemammalsmodel organismsnonrodent animalstranslational research

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Area of Science:

  • Oncology
  • Comparative Medicine
  • Animal Models

Background:

  • Colorectal cancer (CRC) is a global health challenge with poor outcomes for metastatic and drug-resistant cases.
  • Rodent models are standard in CRC research but face limitations due to ethical concerns and the need for better simulations.
  • Developing novel therapeutic strategies necessitates deeper understanding of CRC mechanisms.

Purpose of the Study:

  • To review non-rodent animal models utilized in colorectal cancer research.
  • To highlight the advantages of these alternative models in studying CRC.
  • To explore their contribution to understanding CRC carcinogenesis, metastasis, and drug resistance.

Main Methods:

  • Literature review of non-rodent models in CRC research.
  • Identification of model organisms (zebrafish, fruit flies, C. elegans) and mammals (rabbits, dogs, pigs).
  • Inclusion of the chorioallantoic membrane (CAM) model.

Main Results:

  • Non-rodent models provide diverse advantages for specific aspects of CRC research.
  • Zebrafish, fruit flies, C. elegans, CAM, rabbits, dogs, and pigs have been successfully employed.
  • These models facilitate novel insights into CRC development and treatment resistance.

Conclusions:

  • Non-rodent models are valuable alternatives to rodents in CRC research.
  • They offer unique platforms for investigating CRC biology and testing new therapies.
  • Expanding the use of these models can accelerate the development of effective CRC treatments.