Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in hospitals have...
Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The flux of energy in critical illness and the obesity paradox.

Physiological reviews·2025
Same author

Identification of Clinically Significant Cytokine Signature Clusters in Patients With Septic Shock.

Critical care medicine·2023
Same author

Disruption of the circadian rhythm of melatonin: A biomarker of critical illness severity.

Sleep medicine·2023
Same author

Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial.

The Lancet. Respiratory medicine·2023
Same author

Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure.

Nature communications·2022
Same author

Immediate Effect of Mechanical Ventilation Mode and Sedative Infusion on Measured Diaphragm Thickness.

Annals of the American Thoracic Society·2022
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Creating the animated intensive care unit.

Jesse B Hall1

  • 1Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, USA. jhall@medicine.bsd.uchicago.edu

Critical Care Medicine
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Minimize sedation and neuromuscular blockade in critical care to improve patient recovery. New strategies and medications can reduce adverse effects, enabling earlier physiotherapy and nutrition, and shortening rehabilitation needs.

More Related Videos

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

Related Experiment Videos

Last Updated: Jun 5, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

Area of Science:

  • Critical care medicine
  • Intensive care unit (ICU) management

Background:

  • Critical care has advanced, improving life support for multi-organ failure.
  • Current management often involves heavy sedation, immobilization, and mechanical ventilation, assumed necessary for therapy.
  • Adverse effects of this intensive approach are increasingly recognized.

Purpose of the Study:

  • To evaluate the benefits of minimizing neuromuscular blockade and sedation in critically ill patients.
  • To explore alternative strategies for critical care management.
  • To identify methods that promote earlier patient interaction and recovery.

Main Methods:

  • Review of observational studies and interventional trials.
  • Focus on noninvasive ventilation and patient-ventilator synchrony.
  • Implementation of sedation strategies to prevent drug accumulation.
  • Use of peripheral μ-receptor antagonists like methylnaltrexone.
  • Introduction of agents like dexmedetomidine for analgesia and anxiolysis.

Main Results:

  • Minimizing sedation and neuromuscular blockade can avoid extreme immobilization.
  • Earlier physiotherapy and improved gut motility are possible.
  • Reduced opiate administration offers neuropsychiatric and neuromuscular benefits.
  • Newer drugs may provide better analgesia with fewer side effects.
  • Facilitates earlier and more complete enteral nutrition.

Conclusions:

  • A less controlled, more interactive approach to critical care is warranted.
  • Minimizing sedation and neuromuscular blockade can accelerate recovery.
  • This approach reduces the need for prolonged post-ICU rehabilitation.
  • Newer pharmacologic agents support these evolving critical care strategies.