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Postoperative meningitis in patients with cervical cord tumor: a case report

Yoshiharu Kawaguchi1, Shoji Seki, Taketoshi Yasuda

  • 1Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan.

Asian Spine Journal
|December 18, 2010
PubMed

Insights

Postoperative meningitis after spinal surgery can be life-threatening. Linezolid (LZD) effectively treated a case of methicillin-resistant Staphylococcus epidermidis meningitis with cerebrospinal fluid leakage, suggesting its potential as a first-choice treatment.

Area of Science:

  • Neurosurgery
  • Infectious Diseases
  • Pharmacology

Background:

  • Postoperative meningitis following spinal surgery is a rare but serious complication.
  • Methicillin-resistant Staphylococcus epidermidis (MRSE) poses a significant treatment challenge.
  • Cerebrospinal fluid leakage can exacerbate surgical site infections.

Purpose of the Study:

  • To report a case of postoperative meningitis caused by MRSE after cervical tumor resection.
  • To evaluate the efficacy of Linezolid (LZD) in treating MRSE meningitis with cerebrospinal fluid leakage.
  • To assess the potential of LZD as a primary treatment for such infections.

Main Methods:

  • Surgical debridement and dural repair were performed.
  • Intravenous administration of Linezolid (LZD) was initiated.
  • Clinical and microbiological outcomes were monitored.

Main Results:

  • Successful eradication of MRSE infection.
  • Resolution of meningitis and cerebrospinal fluid leakage.
  • Complete recovery without neurological sequelae.

Conclusions:

  • Linezolid (LZD) demonstrated high efficacy in treating postoperative MRSE meningitis.
  • LZD is a viable first-line option for managing MRSE meningitis, especially with CSF leakage.
  • This case supports the use of LZD in challenging postsurgical infections.
Keywords:
CSF leakageLinezolidMethicillin-resistant Staphylococcus epidermidisPostoperative meningitisSurgical site infection

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