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Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: Jun 5, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

[Epigenetics, genomic imprinting and developmental disorders].

Yves Le Bouc1, Sylvie Rossignol, Salah Azzi

  • 1UPMC ParisVI-INSERM UMRS.938, Paris, France. yves.lebouc@trs.aphp.fr

Bulletin De L'Academie Nationale De Medecine
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

Genomic imprinting, an epigenetic process, regulates gene expression and parental origin. Disruptions in DNA methylation cause growth disorders like Beckwith-Wiedemann syndrome, with potential links to assisted reproductive technologies.

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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Related Experiment Videos

Last Updated: Jun 5, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Area of Science:

  • Epigenetics and Gene Regulation
  • Developmental Biology
  • Genomic Imprinting

Context:

  • DNA methylation is a key epigenetic modification regulating gene expression.
  • Genomic imprinting involves parental origin-dependent epigenetic marking for monoallelic gene expression.
  • Imprinted genes are crucial for embryonic and fetal growth, with critical reprogramming periods in gametogenesis and early development.

Purpose:

  • To explore the role of epigenetic reprogramming in genomic imprinting.
  • To investigate the causes and consequences of imprinting defects, including growth disorders.
  • To examine the potential impact of assisted reproductive technologies (ART) on imprinting.

Summary:

  • Epigenetic reprogramming during gametogenesis and fertilization establishes and maintains DNA methylation patterns.
  • Disruption of genomic imprinting, particularly in the 11p15 region, leads to growth disorders like Beckwith-Wiedemann syndrome (BWS) and Russell-Silver syndrome (RSS).
  • ART may be associated with altered imprinting, suggesting a broader dysregulation of DNA methylation maintenance involving trans-acting factors.

Impact:

  • Understanding imprinting defects is crucial for diagnosing and managing growth disorders.
  • Identifying the causes of ART-related imprinting errors can improve reproductive technologies.
  • This research highlights the sensitivity of early embryogenesis to epigenetic regulation and environmental factors.