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Updated: Jun 5, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
[The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]
Hui Zheng1, Hong-yi Li, Zi-neng Wang
1Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China.
Aim:
To explore the expression of ER and PR mRNAs in endometrium with endometriosis.
Methods:
The rat model of endometriosis was established, and the expression of ER, PR mRNAs in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR).
Results:
The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P < 0.01). But no difference was observed between eutopic and normal endometrium (P > 0.05). Ratio of ER/PR mRNA in ectopic endometrium was larger than that in eutopic and in normal endometrium (P < 0.01).
Conclusion:
The result illuminates that the increased ER plays a vital role in the onset of endometriosis.
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