Related Experiment Videos
Hemorheologic effects of Meclomen including effect in malignant melanoma
M Mahafzah1, S Stadler, K Qazi
1Department of Medicine, Sister's of Charity Hospital, Buffalo, NY.
Thrombosis Research
|March 15, 1990
Abstract:
Sodium Meclofenamate, (Meclomen) (M) is a non-steroidal anti-inflammatory drug, which inhibits both cyclooxygenases and lipooxygenases of the arachidonic acid cascade (AA). (M) inhibited adenosine diphosphosphate (ADP) induced platelet aggregation, arachidonic acid (AA) induced platelet aggregation and collagen induced platelet aggregation. (M) inhibited platelet factor 3 availability when measured by Stypven clotting time. Red cells from patients with advanced malignancies and normal red cells stored in blood banks exhibited loss of deformability. (M) enhanced red cell deformability in these blood samples.