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Related Concept Videos

Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview

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Related Experiment Video

Updated: Jun 5, 2026

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons
15:01

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons

Published on: August 6, 2012

Variation in base excision repair capacity.

David M Wilson1, Daemyung Kim, Brian R Berquist

  • 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States. wilsonda@mail.nih.gov

Mutation Research
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

Base excision repair (BER) is crucial for DNA damage repair. Genetic variations in BER influence disease risk, highlighting the importance of understanding individual repair capacity.

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Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Base excision repair (BER) is the primary pathway for repairing spontaneous DNA damage.
  • BER handles various lesions including oxidative damage, abasic sites, and single-strand breaks.
  • BER defects are implicated in cancer, neurodegenerative diseases, and immunodeficiency.

Purpose of the Study:

  • To review the variability in base excision repair (BER) capacity among individuals.
  • To explore the functional consequences of genetic variants in BER genes.
  • To discuss the association between BER deficiency and disease risk.

Main Methods:

  • Literature review of studies on DNA repair gene variability.
  • Analysis of research linking BER gene polymorphisms to disease susceptibility.
  • Examination of current assays for measuring BER capacity.

Main Results:

  • Significant sequence variability exists in DNA repair genes.
  • Specific BER gene polymorphisms are associated with increased risk for various cancers.
  • Individual differences in BER capacity can impact disease susceptibility.

Conclusions:

  • Understanding the functional impact of BER genetic variants is essential.
  • BER capacity assays are valuable tools for assessing disease risk.
  • Further research into BER deficiency and disease is warranted.