Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
The Pituitary Gland01:17

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of postoperative sacroiliac joint dysfunction and distal failure after iliac and S2-alar-iliac spinopelvic fixation.

Journal of neurosurgery. Spine·2025
Same author

Considering the Effects of Age and Patient Factors on Subsidence and Implant Selection in Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study of 261 Patients.

Clinical spine surgery·2025
Same author

Increasing pelvic tilt after lumbosacral fusion predicts higher frequency of posttreatment sacroiliac joint fusion.

Journal of neurosurgery. Spine·2025
Same author

How Reliable is the Assessment of Fusion Status Following ACDF Using Dynamic Flexion-Extension Radiographs?

Global spine journal·2024
Same author

The Utility of the Validated Intraoperative Bleeding Scale in Thoracolumbar Spine Surgery: A Single-Center Prospective Study.

Global spine journal·2024
Same author

A 10-Year Retrospective Review on the Use of Prophylactic Spinal Reconstruction in Spinal Surgery Involving High-Risk Patients.

Annals of plastic surgery·2023
Same journal

A systematic scoping review of cancer-related anemia treatment: Comparative trial outcomes, current guidelines, and future perspectives.

Seminars in oncology·2026
Same journal

Steroid-induced tumor lysis syndrome in solid tumors: A case report and review of the literature.

Seminars in oncology·2026
Same journal

PSMA PET/CT staging in intermediate-risk prostate cancer: Toward risk-adapted implementation.

Seminars in oncology·2026
Same journal

Angiogenesis and the corresponding antiangiogenic therapy in gastroenteropancreatic neuroendocrine neoplasms.

Seminars in oncology·2026
Same journal

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.

Seminars in oncology·2026
Same journal

Physics-informed machine learning for tumor microenvironment-responsive nanomedicine: Recent updates.

Seminars in oncology·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Pituitary carcinoma.

Charles A Sansur1, Edward H Oldfield

  • 1Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21202, USA. csansur@smail.umaryland.edu

Seminars in Oncology
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

Pituitary carcinoma, a rare metastatic pituitary tumor, presents with endocrine or mass effect symptoms. Recent findings show significant response to chemotherapy, offering new treatment avenues.

More Related Videos

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Related Experiment Videos

Last Updated: Jun 5, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Pituitary carcinoma is a rare but increasingly recognized malignant pituitary tumor characterized by distant metastasis.
  • These tumors often exhibit endocrine activity, leading to hormonal imbalances, or cause symptoms due to mass effect in the sellar region.

Purpose of the Study:

  • This review aims to discuss the diagnosis and clinical features of pituitary carcinomas.
  • It will also cover immunohistochemistry, cytogenetics, and current treatment strategies for this rare malignancy.

Main Methods:

  • Review of existing literature on pituitary carcinoma.
  • Analysis of diagnostic criteria, clinical presentations, and pathological features.
  • Evaluation of treatment outcomes, including surgery and chemotherapy.

Main Results:

  • Pituitary carcinomas are defined by distant metastasis and can present with endocrine hyperfunction or mass effect symptoms.
  • Surgical debulking remains a primary treatment for the sellar mass.
  • Emerging evidence indicates a significant response of these tumors to systemic chemotherapy.

Conclusions:

  • Accurate diagnosis and understanding of clinical features are crucial for managing pituitary carcinoma.
  • Systemic chemotherapy represents a promising therapeutic option for pituitary carcinoma, potentially improving patient outcomes.