Related Experiment Video
Updated: Jun 5, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a
Adrija Kumar Datta1, Srisailesh Vitthala, Amanda Tozer
1Centre for Reproductive Medicine, St Bartholomew's Hospital, London, United Kingdom. adrija65@yahoo.com
Abstract:
In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%, respectively). The findings that LDF protocol improved the clinical outcome in older women, or when LDF followed an unsuccessful IVF/intracytoplasmic sperm injection (ICSI) cycle with DR (LDF: 19.4% vs. DR: 9.76% and LDF: 13.9% vs. DR: 4.2% respectively), need further evaluation through randomized trials.
