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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Coagulation and autoimmunity in scleroderma interstitial lung disease.

Anna Ludwicka-Bradley1, Richard M Silver, Galina S Bogatkevich

  • 1Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Seminars in Arthritis and Rheumatism
|December 21, 2010
PubMed
Summary

Thrombin, a key part of blood coagulation, drives autoimmune responses and fibrosis in systemic sclerosis-associated interstitial lung disease (SSc-ILD). Understanding this link offers new therapeutic targets for this deadly condition.

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Area of Science:

  • Immunology
  • Rheumatology
  • Pulmonology
  • Hematology

Background:

  • Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a leading cause of mortality in scleroderma.
  • SSc-ILD involves irreversible and progressive fibrotic lung tissue damage.
  • Autoimmune processes are central to SSc-ILD pathogenesis.

Purpose of the Study:

  • To review the role of coagulation, specifically thrombin, in autoimmune-mediated tissue injury and fibrosis.
  • To explore the connection between coagulation pathways and the development of SSc-ILD.

Main Methods:

  • A literature search was conducted using PubMed.
  • Keywords included autoimmunity, coagulation, pulmonary fibrosis, and scleroderma.
  • Articles published up to October 2010 were reviewed.

Main Results:

  • Thrombin activation is an early event in tissue injury and contributes to autoimmune responses in SSc.
  • Thrombin promotes the activation of pathogenic Th2 lymphocytes.
  • Thrombin influences tissue repair, induces myofibroblast differentiation, and stimulates the secretion of pro-immune and profibrotic factors, which can act as autoantigens in SSc-ILD.

Conclusions:

  • Linking autoimmunity and coagulation provides novel insights into SSc-ILD pathogenesis.
  • Thrombin plays a significant role in the development and progression of SSc-ILD.
  • Targeting coagulation pathways may offer new therapeutic strategies for SSc-ILD.