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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Selenium and pseudoexfoliation syndrome.
Ayça Yilmaz1, Lokman Ayaz, Lülüfer Tamer
1Department of Ophthalmology, Mersin University Faculty of Medicine, Mersin, Turkey. aycayilmaz@yahoo.com
American Journal of Ophthalmology
|December 21, 2010
Summary
Patients with pseudoexfoliation (PEX) syndrome have lower selenium levels in eye tissues and serum. This finding suggests selenium
Area of Science:
- Ophthalmology
- Trace Element Research
- Biochemistry
Background:
- Pseudoexfoliation (PEX) syndrome is an ocular condition.
- Selenium (Se) is an essential trace element with antioxidant properties.
- The role of selenium in PEX pathogenesis is not fully understood.
Purpose of the Study:
- To quantify selenium levels in aqueous humor, conjunctival specimens, and serum of PEX patients.
- To compare selenium levels between PEX patients and controls.
- To elucidate the potential role of selenium in PEX syndrome development.
Main Methods:
- A prospective case-control study design.
- Inclusion of 27 PEX patients and 20 control subjects undergoing cataract surgery.
- Exclusion of patients with confounding ophthalmic or systemic conditions.
- Collection of aqueous humor, conjunctival specimens, and serum during surgery.
- Measurement of selenium levels using atomic absorption spectrophotometry.
Main Results:
- Significantly lower selenium levels were observed in the aqueous humor of PEX patients compared to controls (P < .001).
- Conjunctival specimens from PEX patients also showed significantly lower selenium levels (P < .001).
- Serum selenium levels were lower in PEX patients but did not reach statistical significance (P = .325).
Conclusions:
- Reduced selenium levels in ocular tissues and serum of PEX patients are evident.
- These findings support the hypothesis that impaired antioxidant defense contributes to PEX pathogenesis.
- Selenium deficiency may play a role in the development and progression of pseudoexfoliation syndrome.
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