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Updated: Jun 5, 2026
09:31
Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices
Published on: March 27, 2019
Ordered mesoporous silicates as matrices for controlled release of drugs
1National Institute of Chemistry, Ljubljana, Slovenia.
Acta Pharmaceutica (Zagreb, Croatia)
|December 21, 2010
Summary
Ordered mesoporous silicates enhance drug release kinetics for poorly soluble drugs. Functionalized surfaces enable tailored, stimuli-responsive drug delivery systems with proven in vitro efficacy and biocompatibility.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Ordered mesoporous silicates (OMS) are increasingly investigated for drug delivery applications.
- These materials offer high surface area and tunable pore structures beneficial for drug encapsulation.
- Enhancing the release kinetics of poorly soluble drugs remains a significant challenge in pharmaceutical formulation.
Purpose of the Study:
- To review the efficacy of OMS as drug delivery devices.
- To explore factors influencing drug release from OMS matrices.
- To highlight the potential of functionalized OMS for stimuli-responsive drug delivery.
Main Methods:
- Literature review of selected cases involving OMS and drug delivery.
- Analysis of itraconazole incorporation within an SBA-15 matrix.
- Discussion of surface functionalization strategies for OMS.
Main Results:
- Mesoporous silicates effectively enhance the release kinetics of poorly soluble drugs.
- Critical factors affecting drug structure and release from SBA-15 were identified.
- Functionalization enables the development of pH, ion, redox, magnetic, and light-responsive systems.
Conclusions:
- OMS represent a powerful platform for improving drug delivery.
- Surface modification of OMS facilitates the design of advanced stimuli-responsive systems.
- In vitro studies confirm the efficiency and biocompatibility of these developed systems.
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