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Updated: Jun 5, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
Published on: November 4, 2022
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
Abdul Hakkim1, Tobias A Fuchs, Nancy E Martinez
1Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin.
Abstract:
The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.
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