[Risk factors associated with failure from endoscopic therapy in acute non-variceal upper gastrointestinal bleeding]

Area of Science:

• Gastroenterology
• Endoscopic Therapeutics
• Hepatology

Context:

• Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a significant clinical challenge.
• Endoscopic therapy is a primary treatment modality for ANVUGIB.
• Identifying factors predicting treatment failure is crucial for optimizing patient management.

Purpose:

• To identify risk factors associated with the failure of endoscopic therapy in patients with ANVUGIB.
• To analyze clinical, laboratory, and endoscopic findings predictive of treatment outcomes.
• To inform clinical decision-making for high-risk patients.

Summary:

• A retrospective cohort study of 223 ANVUGIB patients was conducted.
• Multivariable logistic regression identified shock, history of gastrointestinal bleeding, low platelet count (PLT<100×10⁹/L), active spurting of blood, and lesion size (≥2.0 cm) as significant risk factors for endoscopic therapy failure.
• Comorbidities and active bleeding were associated with the need for surgery or death.

Impact:

• Findings highlight specific patient profiles at high risk for continued bleeding or rebleeding after endoscopic intervention.
• Suggests that patients with identified risk factors may benefit from aggressive post-hemostasis care.
• Contributes to improved risk stratification and management strategies for ANVUGIB.