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Related Experiment Video

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Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

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Refilling Intracellular Calcium Stores.

Changwon Kho¹, Ahyoung Lee, Dongtak Jeong

¹Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY10029, USA.

Drug Discovery Today. Disease Mechanisms

|December 21, 2010

Summary

Calcium ion regulation by the sarcoplasmic reticulum (SR) is crucial for heart function. This review explores how SR protein changes in heart failure disrupt calcium (Ca2+) balance and impair contraction, highlighting therapeutic targets.

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Last Updated: Jun 5, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

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Published on: May 7, 2013

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

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Published on: October 28, 2014

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

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Published on: May 19, 2017

Area of Science:

Cardiology
Molecular Biology
Cell Physiology

Background:

Cardiac cells rely on precise calcium ion (Ca2+) regulation for normal contraction.
The sarcoplasmic reticulum (SR) is a key organelle managing intracellular Ca2+ movements.
Dysregulation of SR proteins contributes to the pathophysiology of heart failure.

Purpose of the Study:

To review the role of SR Ca2+ regulators in cardiac disease.
To discuss novel therapeutic strategies targeting SR Ca2+ pathways in heart failure.

Main Methods:

Literature review of studies on SR Ca2+ handling in cardiac function and disease.
Analysis of current research on therapeutic interventions targeting SR proteins.

Main Results:

Alterations in SR Ca2+ regulatory proteins are linked to abnormal Ca2+ homeostasis in failing hearts.
These disruptions lead to impaired cardiomyocyte contractility.
Emerging therapeutic strategies aim to restore normal SR Ca2+ handling.

Conclusions:

Targeting SR Ca2+ regulatory proteins offers a promising avenue for treating heart failure.
Understanding SR Ca2+ dynamics is critical for developing effective cardiac therapies.