Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Multimachine Stability01:25

Multimachine Stability

Multimachine stability analysis is crucial for understanding the dynamics and stability of power systems with multiple synchronous machines. The objective is to solve the swing equations for a network of M machines connected to an N-bus power system.
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Signal-to-Noise Ratio in Estimating and Testing the Mediation Effect: Structural Equation Modeling versus Path Analysis with Weighted Composites.

Psychometrika·2026
Same author

Servant Leadership in Higher Education: A Graded Response Model Approach to Item Response Theory Analysis.

Psychological reports·2025
Same author

Signal-to-Noise Ratio in Estimating and Testing the Mediation Effect: Structural Equation Modeling versus Path Analysis with Weighted Composites.

Psychometrika·2024
Same author

Which method delivers greater signal-to-noise ratio: Structural equation modelling or regression analysis with weighted composites?

The British journal of mathematical and statistical psychology·2023
Same author

Replies to comments on "Which method delivers greater signal-to-noise ratio: Structural equation modelling or regression analysis with weighted composites?" by Yuan and Fang (2023).

The British journal of mathematical and statistical psychology·2023
Same author

A systematic framework for defining R-squared measures in mediation analysis.

Psychological methods·2023

Related Experiment Video

Updated: Jun 5, 2026

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
13:54

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

Published on: August 18, 2023

Finite Normal Mixture SEM Analysis by Fitting Multiple Conventional SEM Models.

Ke-Hai Yuan1, Peter M Bentler

  • 1University of Notre Dame.

Sociological Methodology
|December 21, 2010
PubMed
Summary

This study introduces a two-stage maximum likelihood (ML) method for normal mixture structural equation modeling (SEM). This approach provides robust statistical inference, even with distributional misspecification, improving model accuracy and efficiency.

Related Experiment Videos

Last Updated: Jun 5, 2026

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
13:54

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

Published on: August 18, 2023

Area of Science:

  • Statistics
  • Quantitative Psychology
  • Econometrics

Background:

  • Structural Equation Modeling (SEM) traditionally assumes data normality.
  • Normal mixture SEM extends SEM to handle non-normal data but is sensitive to model misspecification.
  • Existing methods struggle with distributional violations and model complexity.

Purpose of the Study:

  • To propose a novel two-stage maximum likelihood (ML) approach for normal mixture SEM.
  • To develop statistical inference robust to distributional misspecification.
  • To enhance model evaluation and flexibility in mixture modeling.

Main Methods:

  • A two-stage ML estimation process is introduced.
  • Stage-1 estimates saturated means and covariances with a sandwich-type covariance matrix.
  • Stage-2 evaluates structural models using stage-1 outputs, allowing conventional SEM diagnostics.

Main Results:

  • The two-stage ML approach yields accurate models despite violated normal mixture assumptions and initial misspecification.
  • It demonstrates computational efficiency and avoids confounding model specification with component number.
  • The Bayesian Information Criterion (BIC) shows improved robustness to distribution violations at moderate sample sizes.

Conclusions:

  • The proposed two-stage ML method offers a flexible and robust alternative for normal mixture SEM.
  • It effectively handles distributional misspecification and model complexity.
  • This framework facilitates the integration of new developments in mixture modeling literature.