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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

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Related Experiment Video

Updated: Jun 5, 2026

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams
09:00

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

[Mental pain: is it a symptom?].

Raphaël Gaillard1, Henry Loo, Jean-Pierre Olie

  • 1Hôpital Sainte Anne, 1, rue Cabanis, 75014 Paris. raphael.gaillard@normalesup.org

Bulletin De L'Academie Nationale De Medecine
|December 22, 2010
PubMed
Summary
This summary is machine-generated.

Mental pain, or psychache, shares neurological pathways with physical pain. This finding suggests novel treatment approaches for depression and melancholic conditions.

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Last Updated: Jun 5, 2026

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams
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Published on: July 7, 2023

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
07:08

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pain Research

Context:

  • Psychiatrists manage diverse emotional states, including sadness and exaltation.
  • The concept of 'psychache' describes depression with melancholic features.
  • The neurological basis of mental pain remains incompletely understood.

Purpose:

  • To explore the pathophysiological underpinnings of mental pain (psychache).
  • To investigate the relationship between mental pain and the neurological substrate of physical pain.
  • To examine the implications of this relationship for treatment and prognosis.

Summary:

  • Cognitive studies reveal that the same neurological areas activated by physical pain are also engaged by mental pain.
  • Pathophysiological evidence supports the concept of psychache as a distinct form of suffering.
  • Mental pain is linked to an increased risk of suicide.

Impact:

  • Findings suggest that analgesics, including opiates and ketamine, may offer therapeutic benefits for mental pain.
  • This research opens new avenues for understanding and treating melancholic depression.
  • Understanding the shared neurobiology of mental and physical pain can improve patient outcomes.