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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 5, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

[MicroRNAs and prostate cancer].

Cui-hua Yang1, Chun-ni Zhang

  • 1PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. yanghua_207@163.com

Zhonghua Nan Ke Xue = National Journal of Andrology
|December 22, 2010
PubMed
Summary

MicroRNAs (miRNAs) are small RNAs regulating genes and linked to cancer. Aberrantly expressed prostate miRNAs suggest their role in prostate cancer, with serum miRNAs showing promise as diagnostic biomarkers.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Context:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Aberrant miRNA expression is implicated in various cancers, including prostate cancer.
  • Prostate cancer pathogenesis involves complex molecular mechanisms, potentially including miRNA dysregulation.

Purpose:

  • To investigate the role of microRNAs in prostate cancer development.
  • To explore the potential of serum microRNAs as diagnostic biomarkers for prostate cancer.

Summary:

  • MicroRNAs (miRNAs), approximately 22 nucleotides long, are key post-transcriptional regulators.
  • Dysregulated miRNAs are observed in prostate tissues, suggesting a role in prostate cancer.
  • Human serum and plasma miRNAs are emerging as promising biomarkers for prostate cancer diagnosis.

Impact:

  • Understanding miRNA involvement in prostate cancer can reveal novel therapeutic targets.
  • Serum miRNA detection offers a minimally invasive approach for prostate cancer diagnosis.
  • This research highlights the potential of miRNAs as reliable biomarkers for early prostate cancer detection.