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[Accelerated postoperative radiotherapy in patients with advanced larynx cancer]
Jadwiga Kubrak1, Maria Chosia, Piotr Maj
1Oddzial Kliniczny Radioterapii PAM. jkubrak@wp.pl
Aim:
The aim of study was test efficacy of accelerated postoperative radiotherapy--concomitant boost in patients with advanced larynx cancer.
Methods And Materials:
The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment. Patients had postoperative radiation therapy, conventional (C) or accelerated (CB).
Results:
The 3-year overall survival in CB was 59%, in C--58% (p = 0.2), 3-year locoregional control in CB--83%, in C--75% (p = 0.01), the 3-year disease free survival was in CB--72%, C--66% (p = 0.1).
Conclusion:
Concomitant boost postoperative radiation therapy did not improve overall survival, loco-regional control, disease free survival. Patients with close surgical margins, longer interval between surgery and radiation, high level of hemoglobin, T4 had benefit from accelerated radiotherapy.
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