[Bilateral lesion of locus coeruleus in rats induces haemorrhage in multiple visceral organs]

The haemorrhagic changes of the urinary bladder, as well as that of other visceral organs, were checked histologically in rats being received bilateral electrolytic lesion of the locus coeruleus (LC).

Complete lesion of bilateral LC constantly induced severe haemorrhage of the urinary bladder, accompanied with blood congestion or slight haemorrhage of other visceral organs. Partial lesion of bilateral LC also induced blood congestion or slight haemorrhage in multiple visceral organs, but the urinary bladder did not show haemorrhage change. Reduction of stress by adrenalectomy before lesion of the LC, or administration of antagonist of histamine H2 receptor, had no obvious effect on the haemorrhage of the urinary bladder and histological changes of other visceral organs.

These results indicate that the haemorrhagic change of multiple visceral organs induced by bilateral lesion of the LC in rats is not due to stress, or due to involvement of histamine H2 receptor. The mechanism needs to be studied further.