Related Experiment Video
Updated: Jun 5, 2026
Model of Ischemia and Reperfusion Injury in Rabbits
Published on: November 3, 2023
[The effect of ischemic preconditioning on adenosine phosphate content after spinal cord ischemia in rabbits]
Aim:
To study the effect of ischemic preconditioning (IP) on adenosine phosphate content after spinal cord ischemia in rabbits.
Methods:
We established a lumbar spinal cord ischemia model by inflating the balloon of a 4F Swan-Ganz catheter positioned in the abdominal aorta of the rabbits. All rabbits were divided into sham-operated group, ischemic group and IP group. Adenosine phosphate content in spinal cord of all rabbits was determined at 4 hours, 2 days and 5 days after spinal cord ischemia by using reverse phase HPLC.
Results:
ATP content in lumbar spinal cord of rabbits in ischemic group was markedly reduced (P < 0.01 vs sham-operated group). But in IP group, it was obviously elevated at each time point compared with ischemic group (P < 0.01).
Conclusion:
IP can significantly elevated ATP content in postischemic lumbar spinal cord in rabbits. This may be one of the mechanisms that IP can protect spinal cord from ischemic injury.
