Related Experiment Video
Updated: Jun 5, 2026

Whole-cell Patch-clamp Recordings in Brain Slices
Published on: June 15, 2016
[Effects of temperature on the open-channel density of delayed rectifier K+ channels in hypothalamic neurons]
1Department of Thermal Environmental Medicine, the First Military Medical University, Guangzhou 510515.
Aim And Methods:
To observe the effect of temperature on multi-order open of delayed rectifier K+ channels in hypothalamic-neurons by cell-attached mode of patch-clamp technique.
Results:
With temperature raising, the probability of open-channel recording increased, multichannel open occurred. The density of open - channel on membrane of 32 degrees C, 37 degrees C and 39 degrees C was 0.71, 1.22 and 1.82 channels/microm2 respectively (P < 0.05).
Conclusion:
More Ik of hypothalamus opened with temperature raising, this benefited to the body temperature regulation of neurons in hypothalamus.
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