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[Changes of erythrocyte rheology properties in immigrant subjects at different altitudes and its mechanism]
1Geriatrics Institute, People's Hospital of Qinghai Province, Xining 810007.
Aim:
To explore the influence of altitude changes on red blood cell rheology properties and negative effects caused by it and possible mechanism.
Methods:
Erythrocyte filtration index (EFI), superoxide dismutase (SOD) and Malondialdehyde (MDA) were detected the mechanisms in which EFI changes.
Results:
EFI increased with increasing altitudes and there was a significant different in EFI at the different range of Hb at the same altitude and a significant different in EFI at the similar range of Hb at different altitudes. Correlative analyses showed that EFI was in a negative correlation with SOD activities, relations between EFI and MDA were on the contrary.
Conclusion:
Changes of SOD and MDA with increasing altitudes lead to abnormalities of erythrocyte rheology properties in healthy subjects.
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